This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.
Beilstein J. Org. Chem. 2016, 12, 2823–2827, doi:10.3762/bjoc.12.281
Graphical Abstract
Figure 1: Selected fluorinated polar alicyclic scaffolds.
Scheme 1: Retrosynthetic plan to the preparation of 1,1,3,3-tetrafluorocyclohexane structures.
Scheme 2: Preparation of starting materials 5c and 6a–c.
Scheme 3: Deoxofluorination of diketones 5. Reagents and conditions: a) DAST, DCM, rt, overnight, 4a (traces)...
Scheme 4: Fluorodesulfurisation of bis-dithianes 6. Reagents and conditions: a) NIS, HF·Py, DCM, −78 °C to rt...
Figure 2: X-ray structure of compound 4c. The image shows two molecules stacked with the non-fluorine face po...
Figure 3: 1H NMR spectra of 4c. A) shows the spectrum in [2H8]-toluene, and B) shows the spectrum in chlorofo...
Figure 4: Electrostatic potential map for 4c calculated at the B3LYP/6-311G(d,p) level for an optimised struc...
Beilstein J. Org. Chem. 2014, 10, 18–25, doi:10.3762/bjoc.10.4
Figure 1: The CF2 group in 1c accelerates RCM reactions relative to CHF (1d) and CH2 (1e) and with a similar ...
Figure 2: X-ray structures of a) 1,1,4,4- (3) b) 1,1,7,7- (4) and c) 1,1,6,6- (5) tetrafluorocyclododecanes. ...
Figure 3: Synthesis targets: Palmitic acid analogues 6a–c.
Scheme 1: Synthesis route to 8,8-difluorohexadecanoic acid (6a).
Scheme 2: The synthesis of palmitic acid analogues 6b and 6c.
Figure 4: DSC traces for the three palmitic acid analogues 6a–c.
Figure 5: The X-ray crystal structures of 8,8-difluorohexadecanoic acid (6a).
Figure 6: The X-ray structure of 8,8,11,11-tetrafluorohexadecanoic acid (6c).
Scheme 3: Synthesis route to the tetrafluorinated alkane 27.
Figure 7: The X-ray structure of 8,8,11,11-tetrafluorononadecane (27).
Figure 8: Conformational interconversion of 1,4-di-CF2 motif.